You have asked several questions in different posts, in relation to business taxation. That is welcome, but I would caution you that if you are new to operating a business and want to attempt something ambitious/complex as regards tax arrangements, asking questions piecemeal is unlikely to get you the "right" answer.
For example, you have asked elsewhere about buying or leasing a van, but also about selling your own van to your own company. The answers to one may change quite a bit if you are asking about leasing from yourself, for example.
With regard to this particular question it is unclear whether you are primarily present and/or operating in mainland UK or the Isle of Man. If you are operating in mainland UK but thinking that incorporating your business in the IoM will somehow access more favourable tax treatment, then I should warn you that the place of incorporation of a business is only one aspect of its tax residence status. If you are operating a small company on / from the mainland then it will almost certainly be tax resident in mainland UK even if it has been incorporated elsewhere. While it MAY be possible to have a company that licences IP from overseas, there are a number of reasons as to why that may not be as beneficial as you might at first think.
If you are based in IoM and hope to run a mainland business from there, then that MAY be possible, but the amount of time you spend in mainland UK overseeing things may in turn be relevant - not necessarily in terms of just counting days, but in terms of decision-making and where that is taking place.
So, in short, feel free to ask away, but please note that any advisor here (and there are several here who do this for a living) would warn you, first and foremost, that once you have put together an overall plan in terms of what you want to do, please do make sure to get tailored advice specific to your circumstances from a suitably qualified professional.