It is not possible to say how much the extra Income Tax would be, as it would depend on his exact circumstances for the relevant tax year(s).
There is usually no way to mitigate the interest, as he will have had the benefit of not paying the tax at an earlier date.
His ill health should be taken into account by HMRC - a letter from his doctor may assist, if necessary.
Any penalty may be nominal - depending how sympathetic the HMRC officer is.
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